Dimethyl Sulfate → Methyl 3-methoxy-4-phenylthiobenzoate

HRID 621632ノート

反応式

HRID 621632 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([O:7][CH3:8])=[S:6].[C:18](=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>CC(C)=O>[CH3:18][O:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:5]([O:7][CH3:8])=[S:6]

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 54152449Methyl 3-hydroxy-4-phenylthiobenzoate

生成物 1

HCID 53705693Methyl 3-methoxy-4-phenylthiobenzoate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a mixture of methyl 3-hyroxy-4-phenylthiobenzoate (49.11 g), potassium carbonate (27.33 g) and acetone (627 ml) is added dimethyl sulfate (17.85 ml), and the mixture is refluxed with stirring for 6 hours. The reaction mixture is cooled, and the precipitate is separated by filtration and washed with acetone. The filtrate and washings are combined and concentrated under reduced pressure to give methyl 3-methoxy-4-phenylthiobenzoate.

後処理

  1. temperaturethe mixture is refluxed
  2. temperatureThe reaction mixture is cooled
  3. customthe precipitate is separated by filtration
  4. washwashed with acetone
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-8440b4cb552d42218a6e6e287f51bd36
出典データセット
uspto-grants-1989_04
特許番号
US04824834

反応ノート

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