Sodium Chloride → HCID 19934656、化合物

HRID 621634ノート

反応式

HRID 621634 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1.[C-:18]#[N:19].[Na+].[Cl-].[Na+]>CN(C)C=O>[C:18]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1)#[N:19]

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 19934631HCID 19934631、化合物

生成物 1

HCID 19934656HCID 19934656、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
30 °C

実験手順

The 1-chloromethyl-3-methoxy-4-phenylthiobenzene obtained above is dissolved in N,N-dimethylformamide (200 ml), and thereto is added finely divided sodium cyanide (7.34 g), and the mixture is stirred at 30° C. for 14 hours. To the reaction mixture are added saturated aqueous sodium chloride solution (300 ml) and ice water (300 ml), and the mixture is extracted with ethyl acetate (300 ml×3). The combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3) and dried over anhydrous sodium sulfate to give 1-cyanomethyl-3-methoxy-4-phenylthiobenzene. benzene.

後処理

  1. extractionthe mixture is extracted with ethyl acetate (300 ml×3)
  2. washThe combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3)
  3. dry with materialdried over anhydrous sodium sulfate

出典と根拠

ORDレコード
ord-61188dab6b6a41dea3e4c1e5783cfd8a
出典データセット
uspto-grants-1989_04
特許番号
US04824834

反応ノート

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