Methanol → Methyl 4-phenylthiobenzoate

HRID 621636

反応式

HRID 621636 の反応式
[C:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=[S:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[CH3:21]O>>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([O:13][CH3:21])=[S:12])=[CH:14][CH:15]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 178526127HCID 178526127、化合物

生成物 1

HCID 54459547Methyl 4-phenylthiobenzoate

実験手順

A mixture of 4-phenylthiobenzoic acid (26.29 g), conc. sulfuric acid (5 ml) and methanol (400 ml) is refluxed with stirring for 10 hours. After the reaction is completed, the reaction mixture is concentrated under reduced pressure, and to the residue is added ethyl acetate (400 ml). The mixture is washed with saturated aqueous sodium chloride solution (200 ml×3), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give methyl 4-phenylthiobenzoate (27.44 g).

後処理

  1. temperatureis refluxed
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. additionto the residue is added ethyl acetate (400 ml)
  4. washThe mixture is washed with saturated aqueous sodium chloride solution (200 ml×3)
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-575a839db3484b71b69b3f4bec7ae1ed
出典データセット
uspto-grants-1989_04
特許番号
US04824834

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