Sodium Chloride → [4-(Phenylsulfanyl)phenyl]acetonitrile

HRID 621638

反応式

HRID 621638 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[C-:16]#[N:17].[Na+].[Cl-].[Na+]>>[C:16]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1)#[N:17]

参加物

4

反応物 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 710221-(Chloromethyl)-4-(phenylthio)benzene

生成物 1

HCID 238605[4-(Phenylsulfanyl)phenyl]acetonitrile収率 100.7%

実験手順

The 1-chloromethyl-4-phenylthiobenzene (3.0 g) is dissolved in N,N-dimemthylformamide (15 ml), and thereto is added finely divided sodium cyanide (1.0 g), and the mixture is stirred at room temperature for 17 hours. To the reaction mixture are added saturated aqueous sodium chloride solution (50 ml) and ice water (50 ml), and the mixture is extracted with ethyl acetate (100 ml×3). The combined extracts are washed with saturated aqueous sodium chloride solution (50 ml×3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-cyanomethyl-4-phenylthiobenzene (2.9 g).

後処理

  1. extractionthe mixture is extracted with ethyl acetate (100 ml×3)
  2. washThe combined extracts are washed with saturated aqueous sodium chloride solution (50 ml×3)
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-369e39a2172b42238e3a4dac89f46441
出典データセット
uspto-grants-1989_04
特許番号
US04824834

関連ノート

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