Sodium Chloride → 1-Cyanomethyl-3-methyl-4-phenylthiobenzene

HRID 621641ノート

反応式

HRID 621641 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1.[C-:17]#[N:18].[Na+].[Cl-].[Na+]>>[C:17]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1)#[N:18]

参加物

4

反応物 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 199346681-Chloromethyl-3-methyl-4-phenylthiobenzene

生成物 1

HCID 199346671-Cyanomethyl-3-methyl-4-phenylthiobenzene

実験手順

The 1-chloromethyl-3-methyl-4-phenylthiobenzene obtained above is dissolved in N,N-dimemthylformamide (56 ml), and thereto is added finely divided sodium cyanide (18.16 g), and the mixture is stirred at room temperature overnight. To the reaction mixture are added saturated aqueous sodium chloride solution (300 ml) and ice water (300 ml), and the mixture is extracted with ethyl acetate (300 ml×3). The combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-cyanomethyl-3-methyl-4phenylthiobenzene (45.95 g).

後処理

  1. dissolutionabove is dissolved in N,N-dimemthylformamide (56 ml)
  2. extractionthe mixture is extracted with ethyl acetate (300 ml×3)
  3. washThe combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3d4f818ae6e04d67862bb1e5bb89dc12
出典データセット
uspto-grants-1989_04
特許番号
US04824834

反応ノート

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