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1,3-Cyclohexanedione → Benzonitrile, 2-((3-oxo-1-cyclohexen-1-yl)amino)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Cyclohexanedione | HCID 10434 | — |
| 反応物 | 2-Aminobenzonitrile | HCID 72913 | — |
| 触媒 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Benzonitrile, 2-((3-oxo-1-cyclohexen-1-yl)amino)- | HCID 184360 | 93% |
反応手順
A mixture of 2-aminobenzonitrile (120 g) and 1,3-cyclohexandione (120 g) in water (400 ml) was heated to 40° and 4-methylbenzenesulfonic acid monohydrate (6.2 g) was added, with stirring. The mixture was stirred at 40° for 1 hr. The mixture was filtered, and the filter cake was washed with water to provide 200 g (93%) of 2-(3-oxocyclohexen-1-yl)aminobenzonitrile, mp 191.4°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05247091 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-695590d38ba04361a966067c6963981f |
| 出典メモ | uspto-grants-1993_09 |