Hydrochloric Acid → 9-Amino-1,2,3,4-tetrahydroacridine hydrate

HRID 6221

反応式

HRID 6221 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:10]1(=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.Cl>>[OH2:16].[NH2:5][C:4]1[C:3]2[C:2]([N:1]=[C:10]3[C:11]=1[CH2:12][CH2:13][CH2:14][CH2:15]3)=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

4

反応物 3

HCID 313Hydrochloric Acid2 回HCID 7967CyclohexanoneHCID 729132-Aminobenzonitrile

生成物 1

HCID 197952369-Amino-1,2,3,4-tetrahydroacridine hydrate収率 67%

実験手順

A mixture of 2-aminobenzonitrile (120 g), cyclohexanone (115.8 ml), conc hydrochloric acid (9.2 ml), and cuprous chloride (1.21 g) was heated under reflux for 3 days, with stirring. At the end of each 24 hr period, additional cuprous chloride (1.21 g) was added. At the end of the 3rd day, additional conc hydrochloric acid (47.3 ml) was added, and the mixture was cooled to ambient temperature. The precipitate was collected and washed with 10% hydrochloric acid to provide 160 g (67.0%) of 9-amino-1,2,3,4-tetrahydroacridine hydrate, mp 180°-185°.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 days
  3. customThe precipitate was collected
  4. washwashed with 10% hydrochloric acid

出典と根拠

ORDレコード
ord-ef26d013c4cc405e8068592ad63dfa26
出典データセット
uspto-grants-1993_09
特許番号
US05247091

関連ノート

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