関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | HCID 14257102 | HCID 14257102 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | Aluminiumhydride | HCID 21584524 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | HCID 14257103 | HCID 14257103 | — |
反応手順
5-Carbethoxy-1,4-dimethyl-2-(4-methoxybenzylthio)imidazole (31 g, 0.1 mole) dissolved in ether (250 ml) was added dropwise to a solution of aluminum hydride in ether stirred at 0° C. [the aluminum hydride in ether was prepared by adding lithium aluminum hydride (7.4 g, 0.19 mole) in portions to a solution of aluminum chloride (8.6 g, 0.065 mole) stirred in ether (200 ml) at 0° C⟧ The mixture was stirred at 0° C. for 1 hour, treated with water and 10% aqueous sodium hydroxide, filtered and concentrated in vacuo. The resulting oil was dissolved in methylene chloride, dried with magnesium sulfate, filtered and concentrated in vacuo to give 1,4-dimethyl-5-hydroxymethyl-2-(4-methoxybenzylthio)imidazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04769386 |
|---|
| 出典データセット | uspto-grants-1988_09 |
|---|
| ORD ID | ord-6a7dc7cd8ded4a3c9867fe85a2edfb94 |
|---|
| 出典メモ | uspto-grants-1988_09 |
|---|
