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Water → 6-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Chloroethyldiisopropylammonium chloride | HCID 77942 | — |
| 反応物 | 6-Bromophthalazin-1(2h)-one | HCID 11535918 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 6-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one | HCID 21293334 | — |
反応手順
6-Bromophthalazinone (11.2 gm, 0.05 mole) was slurried in 80 ml dimethylsulfoxide. To this was added 22 ml 45% KOH (0.25 mole). After stirring 10 minutes 16 gm 2-(diisopropylamino)ethyl chloride hydrochloride was added and the mixture stirred for 18 hours. A water bath was used to moderate the slightly exothermic reaction (temperature <=25°). Water (100 ml) was added to the reaction mixture, which was then stirred another hour.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04769369 |
| 出典データセット | uspto-grants-1988_09 |
| ORD ID | ord-8beea11fd514416690c0bd6c6de67784 |
| 出典メモ | uspto-grants-1988_09 |