1-[1-(2-Chlorophenyl)butyl]-1H-imidazole-5-carboxylic acid → HCID 23707461、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([N:12]1[C:16]([C:17]([OH:19])=[O:18])=[CH:15][N:14]=[CH:13]1)[CH2:9][CH2:10][CH3:11].C[O-:21].[K+:22]>CO>[OH2:18].[OH2:21].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([N:12]1[C:16]([C:17]([O-:19])=[O:18])=[CH:15][N:14]=[CH:13]1)[CH2:9][CH2:10][CH3:11].[K+:22]参加物
4
実験手順
A mixture of 1 part of 1-[1-(2-chlorophenyl)butyl]-1H-imidazole-5-carboxylic acid, 80 parts of methanol and 35.9 parts of a potassium methoxide solution 0.1N was stirred for 1 hour at reflux temperature. The reaction mixture was evaporated and the residue was dried in a dry pistol at 70° C., yielding 0.34 parts (26.7%) of potassium 1-[1-(2-chlorophenyl)butyl]-1H-imidazole-5 -carboxylate dihydrate; mp. 70.7° C. (compound 2.14).