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Tetrahydrofuran → 1-(N,N-dibutylaminocarbonyloxy)-2-phenylphenanthroimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Dibutylcarbamoyl chloride | HCID 83371 | — |
| 反応物 | 1-Hydroxy-2-phenylphenanthroimidazole | HCID 86742423 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(N,N-dibutylaminocarbonyloxy)-2-phenylphenanthroimidazole | HCID 86742422 | — |
反応手順
10 parts of 1-hydroxy-2-phenylphenanthroimidazole, 8 parts of anhydrous potassium carbonate and 6.7 parts of N,N-dibutylcarbamyl chloride in 100 parts of tetrahydrofuran are refluxed for 5 hours. 100 parts of water and 200 parts of ethyl acetate are then added. The organic phase is washed with water, dried over sodium sulfate and evaporated down under reduced pressure. When the residue is left to stand, 6.6 parts of a solid which has a melting point of 120° C. and is pure according to thin layer chromatography are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04770976 |
| 出典データセット | uspto-grants-1988_09 |
| ORD ID | ord-c08a6d890a5b4754bc072ba3271cb4fa |
| 出典メモ | uspto-grants-1988_09 |