4-Fluorobenzylamine → HCID 21293092、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([NH:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1.CO[C:16]1[C:20](OC)=[N:19][S:18](=[O:23])[N:17]=1.[F:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH2:30])=[CH:27][CH:26]=1>CO>[F:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH:30][C:16]2[C:20]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][C:5]3[C:4]([CH3:13])=[CH:3][C:2]([Br:1])=[CH:7][N:6]=3)=[N:19][S:18](=[O:23])[N:17]=2)=[CH:27][CH:26]=1

参加物

実験手順

3-(5-Bromo-3-methylpyrid-2-ylamino)propylamine (1.0 g) was reacted with 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (0.65 g) in methanol overnight. p-Fluorobenzylamine (0.51 g) was added and the reaction mixture was stirred for 2 hours. The product was filtered off and recrystallised from ethanol to yield 4-(p-fluorobenzylamino)-3-[3-(5-bromo-3-methylpyrid-2-ylamino)propylamino]-1,2,5-thiadiazole-1-oxide (0.77 g, 40%) m.p. 125°-126° C.