Hydrochloric Acid → 2-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride

HRID 622426ノート

反応式

HRID 622426 の反応式
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][Cl:22])[CH2:16][CH2:15]1)(=[O:12])[NH2:11].Cl>O>[ClH:22].[C:10]([O:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[NH:23])[CH2:21][SH:5])[CH2:16][CH2:15]1)(=[O:12])[NH2:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212930032-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride

生成物 1

HCID 212929412-(4-Carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride収率 97.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4.95 g of trisodium phosphorothioate were added to an ice-cooled solution of 6.40 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylchloride hydrochloride in 32 ml of water, and the mixture was stirred at room temperature for 2.5 hours. 28 ml of 1N hydrochloric acid were then added, and the mixture was heated at 60° C. for 30 minutes. The reaction mixture was worked up in the same manner as in Example 1(2), giving 6.20 g of 2-(4-carbamoyloxypiperidin-1-yl)-2-iminoethylmercaptan hydrochloride.

後処理

  1. temperaturethe mixture was heated at 60° C. for 30 minutes

出典と根拠

ORDレコード
ord-28b83350812a47d291f101b3e858f52d
出典データセット
uspto-grants-1988_09
特許番号
US04771046

反応ノート

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