Hydrochloric Acid → 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride

HRID 622429ノート

反応式

HRID 622429 の反応式
P(=[S:5])([O-])([O-])[O-].[Na+].[Na+].[Na+].Cl.[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][Cl:21])[CH2:14]1)(=[O:12])[NH2:11].Cl>O>[ClH:21].[C:10]([CH:13]1[CH2:18][CH2:17][CH2:16][N:15]([C:19](=[NH:22])[CH2:20][SH:5])[CH2:14]1)(=[O:12])[NH2:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 9877537Trisodium thiophosphateHCID 212929612-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride

生成物 1

HCID 212929852-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride収率 105.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.43 g of trisodium phosphorothioate were added to an ice-cooled solution of 2.04 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride in 9.7 ml of water, and the mixture was stirred at room temperature for one hour. 7.9 ml of 1N hydrochloric acid were then added, and the mixture was heated at 50° C. for 30 minutes. The reaction mixture was then worked up in the same manner as in Example 3(2) to give 2.0 g of 2-[(3RS)-3-carbamoylpiperidin-1-yl]-2-iminoethylmercaptan hydrochloride.

後処理

  1. temperaturethe mixture was heated at 50° C. for 30 minutes

出典と根拠

ORDレコード
ord-a8211e0cf8f2420599fee0cf2bb665cb
出典データセット
uspto-grants-1988_09
特許番号
US04771046

反応ノート

読み込み中…