Hydrochloric Acid → (3R)-3-carbamoyloxypyrrolidine hydrochloride

HRID 622444ノート

反応式

HRID 622444 の反応式
[ClH:1].C(OC([N:9]1[CH2:13][CH2:12][C@@H:11]([O:14][C:15](=[O:17])[NH2:16])[CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C.C(Cl)Cl>[ClH:1].[C:15]([O:14][C@@H:11]1[CH2:12][CH2:13][NH:9][CH2:10]1)(=[O:17])[NH2:16]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 14254785(3R)-1-(t-butoxycarbonyl)-3-carbamoyloxypyrrolidine

生成物 1

HCID 67938211(3R)-3-carbamoyloxypyrrolidine hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
30 °C

実験手順

15 ml of a 4M hydrogen chloride solution in ethyl acetate was added to a suspension of 3.00 g of (3R)-1-(t-butoxycarbonyl)-3-carbamoyloxypyrrolidine in 30 ml of methylene chloride, and the mixture was stirred for 30 minutes at 30° C. After completion of the reaction, the precipitated crystals were collected by filtration and washed with ether, giving 1.78 g of the title compound.

後処理

  1. customAfter completion of the reaction
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with ether

出典と根拠

ORDレコード
ord-03c4d8b62c884fa0a2a82c68322cd43b
出典データセット
uspto-grants-1988_09
特許番号
US04771046

反応ノート

読み込み中…