Hydrochloric Acid → (2S,4R)-4-Hydroxypyrrolidine-2-carboxamide Hydrochloride
反応式
C(OC([N:8]1[CH2:12][CH:11]([OH:13])[CH2:10][CH:9]1[C:14](=[O:16])[NH2:15])=O)(C)(C)C.[ClH:17]>C(OCC)(=O)C>[ClH:17].[C:14]([C@@H:9]1[CH2:10][C@@H:11]([OH:13])[CH2:12][NH:8]1)(=[O:16])[NH2:15]参加物
4
実験手順
4.50 g of the product obtained in step (1) above were suspended in 45 ml of ethyl acetate and then 14.9 ml of 4.84M hydrogen chloride in ethyl acetate were added under ice-cooling. The mixture was stirred at 25°-30° C. for 30 minutes, after which the reaction mixture was worked up in the same manner as in Preparation 4(2) to give 3.21 g of the title compound.
後処理
- temperaturecooling
- customafter which the reaction mixture was worked up in the same manner as in Preparation 4(2)
出典と根拠
- ORDレコード
- ord-84313f95726748618abb5dd255a73618
- 出典データセット
- uspto-grants-1988_09
- 特許番号
- US04771046
反応ノート
読み込み中…