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Dimethyl acetylenedicarboxylate → 1-(3-Methoxy-4-ethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl acetylenedicarboxylate | HCID 12980 | — |
| 反応物 | 4-Ethoxy-3-methoxybenzaldehyde | HCID 67116 | — |
| 反応物 | 2-Bromo-3,4,5-trimethoxybenzaldehyde dimethylacetal | HCID 15914458 | — |
| 生成物 | 1-(3-Methoxy-4-ethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene | HCID 13910827 | 67% |
反応手順
2-Bromo-3,4,5-trimethoxybenzaldehyde dimethylacetal, 3-methoxy-4-ethoxybenzaldehyde and dimethyl acetylenedicarboxylate are treated in the same manner as described in Example 1, whereby 1-(3-methoxy-4-ethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene is obtained as colorless needles. Yield: 67%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04771072 |
| 出典データセット | uspto-grants-1988_09 |
| ORD ID | ord-68abce3b5cf34756a1620115ccb7ff85 |
| 出典メモ | uspto-grants-1988_09 |