Glycine, N-formyl-, ethyl ester → N-((3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)formamide

HRID 622654

反応式

HRID 622654 の反応式
[CH:1]([NH:3][CH2:4][C:5]([O:7]CC)=O)=[O:2].[CH:10]1([C:13](=[N:15]O)[NH2:14])[CH2:12][CH2:11]1>CCO>[CH:10]1([C:13]2[N:15]=[C:5]([CH2:4][NH:3][CH:1]=[O:2])[O:7][N:14]=2)[CH2:12][CH2:11]1

参加物

4

反応物 2

HCID 76615Glycine, N-formyl-, ethyl esterHCID 2794666N'-Hydroxycyclopropanecarboximidamide

生成物 1

HCID 14460538N-((3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)formamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl formylaminomethyl-carboxylate (150 mmol) and cyclopropyl carboxamide oxime (100 mmol) in 100% EtOH (100 ml) was charged with Na (200 mg) and crushed molecular sieves (4 Å) (10 g). The mixture thus obtained was stirred and heated to reflux for 8 hours. The mixture was cooled to room temperature, filtered through filter aid and the filtrate was evaporated in vacuo. The oily residue was partitionated into a CHCl3 phase which was dried with Na2SO4 and evaporated.

後処理

  1. customcrushed molecular sieves (4 Å) (10 g)
  2. customThe mixture thus obtained
  3. temperatureheated
  4. temperatureto reflux for 8 hours
  5. filtrationfiltered
  6. filtrationthrough filter aid
  7. customthe filtrate was evaporated in vacuo
  8. dry with materialwas dried with Na2SO4
  9. customevaporated

出典と根拠

ORDレコード
ord-2eb8cf70f1534bf3baceb79fda7498fa
出典データセット
uspto-grants-1988_09
特許番号
US04772599

関連ノート

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