関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | 1-(4-(3-Aminophenyl)thiazol-2-yl)guanidine | HCID 178512611 | — |
| 触媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | HCID 178482140 | HCID 178482140 | — |
反応手順
A mixture of 9.3 g (0.04 mole) of 3-(2-guanidino-4-thiazolyl)benzeneamine, 20 ml of triethylorthoformate, and 2 drops of trifluoroacetic acid is stirred at reflux for 5 hours after which it is concentrated in vacuo. The residue is dissolved in 20 ml of ethanol, the solution cooled to 0° C. and then treated with excess sodium borohydride. The mixture is allowed to warm to room temperature, then stirred at reflux for 4 hours. Upon concentration in vacuo the residue is partitioned between water and dichloromethane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04772622 |
|---|
| 出典データセット | uspto-grants-1988_09 |
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| ORD ID | ord-bf26f55371854a828c4f5bb935c679d5 |
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| 出典メモ | uspto-grants-1988_09 |
|---|
