Bromotrimethylsilane → Bis(trimethylsilyl) (3-phenylpropanoyl)phosphonate

反応式

[CH3:1][Si:2](Br)([CH3:4])[CH3:3].C[O:7][P:8]([C:12](=[O:21])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:11])[O:9]C>>[CH3:1][Si:2]([O:7][P:8]([C:12](=[O:21])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:11])[O:9][Si:2]([CH3:4])([CH3:3])[CH3:1])([CH3:4])[CH3:3]

参加物

反応物 2

HCID 76113Bromotrimethylsilane

HCID 12586015Dimethyl (3-phenylpropanoyl)phosphonate

生成物 1

HCID 54365652Bis(trimethylsilyl) (3-phenylpropanoyl)phosphonate

実験手順

10.7 g of trimethylsilyl bromide were added dropwise at room temperature over a period of 1 hour to 8.5 g of dimethyl(3-phenylpropionyl)phosphonate. The mixture was then stirred for a further 1 hour and then evaporated at 30° C./0.1 mm Hg to give 12.5 g of bis(trimethylsilyl)-(3-phenylpropionyl)phosphonate in the form of a pale yellow oil. This oil was used in the next step without further purification.

後処理

customevaporated at 30° C./0.1 mm Hg

出典と根拠

ORDレコード: ord-90a62951229641b2b99f4cfd835226fd
出典データセット: uspto-grants-1988_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04772701

反応ノート

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