Methanesulfonic Acid → (S)-Methyl piperidine-3-carboxylate
反応式
[CH3:1]S(O)(=O)=O.C(OC([N:13]1[CH2:21][CH2:20][CH2:19][C@H:15]([C:16]([OH:18])=[O:17])[CH2:14]1)=O)(C)(C)C>CO>[NH:13]1[CH2:21][CH2:20][CH2:19][C@H:15]([C:16]([O:18][CH3:1])=[O:17])[CH2:14]1参加物
4
反応条件
- 温度
- 25 °C
実験手順
Methanesulfonic acid (576 mg, 6 mmol) was added to a solution of (S)—N-(tert-butoxycarbonyl)nipecotic acid (1145 mg, 5 mmol) and methanol (5 mL). When the mixture was stirred at 25° C. for 16 hours, (S)-methyl nipecotate was produced, and the object (S)-nipecotic acid was not produced.
出典と根拠
- ORDレコード
- ord-eec1b9c0cf7f4088aed943b49beea7bb
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09302980B2
反応ノート
読み込み中…