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2-(Hydroxyiminomethyl)quinolin-8-ol → 2-(Aminomethyl)quinolin-8-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Hydroxyiminomethyl)quinolin-8-ol | HCID 604733 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(Aminomethyl)quinolin-8-ol | HCID 599967 | 82% |
反応手順
8-Hydroxy-quinoline-2-carboxaldehyde oxime D1 (167 mg, 0.888 mmol) and MeOH (50 mL) was treated under hydrogenolysis conditions (atmospheric H2, catalytic 10% Pd/carbon) at RT. After 4 h, the catalyst was filtered off and the volatiles removed which afforded 2-aminomethyl-quinolin-8-ol E1 as a light brown solid (126 mg, 82%); spectral data of this compound are given in Table 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09302993B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-7056e7ae34984f5c9d181c58b9c74d53 |
| 出典メモ | uspto-grants-2016_04 |