1-(3-(Trifluoromethoxy)phenyl)ethanone → (R)-2-methyl-N-(1-(3-(trifluoromethoxy)phenyl)ethyl)propane-2-sulfinamide

反応式

[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6]([C:10](=O)[CH3:11])[CH:7]=[CH:8][CH:9]=1.[CH3:15][C:16]([S@:19]([NH2:21])=[O:20])([CH3:18])[CH3:17]>>[CH3:15][C:16]([S@:19]([NH:21][CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:14])([F:13])[F:1])[CH:5]=1)[CH3:11])=[O:20])([CH3:18])[CH3:17]

参加物

反応物 2

HCID 7371611-(3-(Trifluoromethoxy)phenyl)ethanone

HCID 10964479tert-Butylsulfinamide, (R)-(+)-

生成物 1

HCID 67511635(R)-2-methyl-N-(1-(3-(trifluoromethoxy)phenyl)ethyl)propane-2-sulfinamide収率 83%

実験手順

The title compound is prepared in 83% yield (0.38 g, a white solid) from 1-(3-(trifluoromethoxy)phenyl)ethanone (0.30 g, 1.47 mmol) and (R)-2-methylpropane-2-sulfinamide by the similar manner in Step-4 of Amine-1.

出典と根拠

ORDレコード: ord-6a79089be5224c26b1c233930fb0814b
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09302991B2

反応ノート

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