Hydrochloric Acid → (5-Bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[ClH:26]>O1CCOCC1>[ClH:26].[Br:1][C:2]1[CH:3]=[C:4]([CH2:14][NH2:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:11])([F:12])[F:13]参加物
4
実験手順
Free base of the title compound is prepared in 97% yield (510 mg, clear colorless oil) from 2-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isoindoline-1,3-dione (770 mg, 1.8 mmol, Step-2) by the similar manner in Step-4 of Amine-24. The obtained amine is suspended in 4M hydrochloric acid in dioxane (3 mL), and the mixture is stirred for 30 minutes at room temperature to give a white precipitate. The precipitate is collected by filtration, washed with dichloromethane, dried in vacuo to give 540 mg (94% yield) of the title compound as a white solid.