Isobutyramide → Methyl 2-isobutyramido-6-methylisonicotinate

反応式

Cl[C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:13]([NH2:18])(=[O:17])[CH:14]([CH3:16])[CH3:15]>>[C:13]([NH:18][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([CH3:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6])(=[O:17])[CH:14]([CH3:16])[CH3:15]

参加物

反応物 2

HCID 68424Isobutyramide

HCID 2759833Methyl 2-Chloro-6-methylisonicotinate

生成物 1

HCID 67509619Methyl 2-isobutyramido-6-methylisonicotinate

実験手順

The title compound is prepared in quantitative yield (1.27 g, yellow syrup) from methyl 2-chloro-6-methylisonicotinate (1.00 g, 5.39 mmol) and isobutyramide by the similar manner in Step-1 of Carboxylic acid-4.

出典と根拠

ORDレコード: ord-035687bf00894351ab50b0a67b89379f
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09302991B2

反応ノート

読み込み中…