Propionyl chloride → 6-propionamido-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide
反応式
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:3]=1.[C:25](Cl)(=[O:28])[CH2:26][CH3:27]>>[C:25]([NH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:23])([F:22])[F:24])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:3]=1)(=[O:28])[CH2:26][CH3:27]参加物
3
実験手順
The title compound is prepared from 6-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (30 mg, 0.09 mmol, Step-1, single enantiomer) and propionyl chloride (12 mg, 0.13 mmol) according to the procedure similar to that described in Step-2 of Example 8.
出典と根拠
- ORDレコード
- ord-c07d1f0915bc46649f2f0bb78afc984d
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09302991B2
反応ノート
読み込み中…