2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-(1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide
反応式
Cl.[F:2][C:3]([F:17])([F:16])[CH2:4][CH2:5][O:6][C:7]1[N:12]=[CH:11][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:9][CH:8]=1.[NH2:18][C:19]1[N:24]=[C:23]([C:25](O)=[O:26])[CH:22]=[CH:21][N:20]=1>>[NH2:18][C:19]1[N:24]=[C:23]([C:25]([NH:15][CH:13]([C:10]2[CH:11]=[N:12][C:7]([O:6][CH2:5][CH2:4][C:3]([F:2])([F:16])[F:17])=[CH:8][CH:9]=2)[CH3:14])=[O:26])[CH:22]=[CH:21][N:20]=1参加物
3
実験手順
The title compound is prepared in 64% yield (100 mg, a white solid) from 1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethanamine hydrochloride (120 mg, 0.4 mmol, Amine-21, single enantiomer) and 2-aminopyrimidine-4-carboxylic acid (62 mg, 0.4 mmol) by the similar manner in Step-1 of Example 8.
出典と根拠
- ORDレコード
- ord-b09dd97d460e49308f6181d1e750d774
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09302991B2
反応ノート
読み込み中…