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Benzylideneacetone → 3-(Aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylideneacetone | HCID 637759 | — |
| 反応物 | 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate | HCID 67124140 | — |
| 生成物 | 3-(Aminomethyl)-6-methyl-4-phenyl-2(1H)-pyridinone | HCID 67124292 | — |
反応手順
The title compound was prepared in the same manner as described for 3-(aminomethyl)-6-methyl-4-propyl-2(1H)-pyridinone (Intermediate 5) using (3E)-4-phenyl-3-buten-2-one (20 g, 137 mmol). LCMS E-S (M+H)=215.0. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.2-12.3 (br s, 1H), 7.88-8.00 (br s, 3H), 7.43-7.51 (m, 3H), 7.29-7.38 (m, 2H), 6.08 (s, 1H), 3.67-3.70 (m, 2H), 2.23 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09446041B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-db35674e3a784b24869104bdd40844d9 |
| 出典メモ | uspto-grants-2016_09 |