[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester → 4-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol

HRID 623676ノート

反応式

HRID 623676 の反応式
C(OC(=O)[N:7]([C:20]1[N:21]([C:25]2[CH:30]=[C:29]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:34])=[CH:27][C:26]=2[OH:35])[N:22]=[N:23][CH:24]=1)[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:31]([C:29]1[CH:30]=[C:25]([N:21]2[C:20]([NH:7][C:8]3[CH:9]=[CH:10][C:11]([N:14]4[CH2:15][CH2:16][O:17][CH2:18][CH2:19]4)=[CH:12][CH:13]=3)=[CH:24][N:23]=[N:22]2)[C:26]([OH:35])=[CH:27][C:28]=1[OH:34])([CH3:33])[CH3:32]

参加物

3

反応物 1

HCID 131735186[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester

生成物 1

HCID 574046064-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol収率 45%

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

A solution of the intermediate from Step E in DCM/TFA (1/1 5 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as slightly brown solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude reaction mixture
  3. customwas purified by column chromatography (DCM/MeOH: 95/5)

出典と根拠

ORDレコード
ord-6104a9e4cc994815ba91308fc49594dd
出典データセット
uspto-grants-2016_04
特許番号
US09302998B2

反応ノート

読み込み中…