tert-butyl 1-(2,4-dihydroxy-5-isopropylphenyl)-1H-1,2,3-triazol-5-yl(4-morpholinobenzyl)carbamate → 4-Isopropyl-6-[5-(4-morpholin-4-yl-benzylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol

HRID 623681ノート

反応式

HRID 623681 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([CH:9]([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:12]1[C:16]([N:17]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)=[CH:28][CH:27]=2)C(=O)OC(C)(C)C)=[CH:15][N:14]=[N:13]1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:9]([C:5]1[CH:4]=[C:3]([N:12]2[C:16]([NH:17][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)=[CH:30][CH:31]=3)=[CH:15][N:14]=[N:13]2)[C:2]([OH:1])=[CH:7][C:6]=1[OH:8])([CH3:11])[CH3:10]

参加物

3

反応物 1

HCID 117678674tert-butyl 1-(2,4-dihydroxy-5-isopropylphenyl)-1H-1,2,3-triazol-5-yl(4-morpholinobenzyl)carbamate

生成物 1

HCID 574046074-Isopropyl-6-[5-(4-morpholin-4-yl-benzylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol収率 50%

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

A solution of the intermediate from Step D in DCM/TFA (1/1, 5 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as slightly brown solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude reaction mixture
  3. customwas purified by column chromatography (DCM/MeOH: 95/5)

出典と根拠

ORDレコード
ord-a6543491e2134c5fab865797e63fae41
出典データセット
uspto-grants-2016_04
特許番号
US09302998B2

反応ノート

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