Water → HCID 68754457、化合物

HRID 624154ノート

反応式

HRID 624154 の反応式
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[CH:6][CH:5]=1)=[C:2]=[O:3].[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][NH:14]1.O>ClCCl>[CH3:15][C:16]1([CH3:17])[C:21]([CH3:13])([CH3:20])[O:12][B:10]([C:7]2[CH:6]=[CH:5][C:4]([NH:1][C:2]([N:14]3[CH2:15][C:16]4[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:13]3)=[O:3])=[CH:9][CH:8]=2)[O:11]1

参加物

5

反応物 3

HCID 962WaterHCID 422478IsoindolineHCID 57416338(4-Isocyanatophenyl)boronic acid

生成物 1

HCID 68754457HCID 68754457、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

500 mg (4-Isocyanatophenyl)boronic acid pinacolester (1.979 mmol) and 365 mg isoindoline (2.97 mmol) were dissolved in 10 ml dichloromethane and the resultant mixture was stirred over night at room temperature. After adding water, the mixture was extracted several times with dichloromethane, the combined organic phases were washed with dried over magnesium sulfate and filtered. The solvent was evaporated under reduced pressure. Column chromatography of the residue with dichloromethane resulted in the title compound.

後処理

  1. extractionthe mixture was extracted several times with dichloromethane
  2. washthe combined organic phases were washed
  3. dry with materialwith dried over magnesium sulfate
  4. filtrationfiltered
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-7530678d204e42f88e0f0a936c3c32da
出典データセット
uspto-grants-2016_04
特許番号
US09302989B2

反応ノート

読み込み中…