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Acetic Acid → 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | P-Toluenesulfonylhydrazide | HCID 15303 | — |
| 反応物 | 2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione | HCID 359353 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one | HCID 67458588 | 51.3% |
反応手順
A solution of 2-((dimethylamino)methylene)cyclohexane-1,3-dione (55 g, 0.329 mol), 2-tosylhydrazine (61.3 g, 0.329 mol) and AcOH (33 mL) in EtOH (540 mL) was heated for 4 h at 70° C. Removed the solvent under reduced pressure and the residue was recrystallized using PE/EA=5/1 to give 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one (49 g, yield 51.3%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09446130B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-ecfba064d9a14925a662eb32c5e86b69 |
| 出典メモ | uspto-grants-2016_09 |