(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde

HRID 624526

反応式

HRID 624526 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]

参加物

4

反応物 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol

生成物 1

HCID 112521382-Amino-4-chlorobenzaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

In a 2 L 3-neck round bottom flask, the stirred solution of (2-amino-4-chlorophenyl)methanol 2 (32 g, 203.82 mmol) in DCM (765 mL), manganese (IV) oxide (150 g, 1.724 mol) was added at rt. The resulting reaction mixture was stirred at rt under argon atmosphere for 40 h. On completion of reaction the reaction mixture was filtered through CELITE™ pad and solid residue was washed thoroughly with DCM (1000 mL). The combined filtrate was concentrated under reduced pressure to give 2-amino-4-chlorobenzaldehyde as orange solid.

後処理

  1. customThe resulting reaction mixture
  2. customOn completion of reaction the reaction mixture
  3. filtrationwas filtered through CELITE™ pad and solid residue
  4. washwas washed thoroughly with DCM (1000 mL)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5996c7a069f843cfb8f7ee178a944e43
出典データセット
uspto-grants-2016_04
特許番号
US09303028B2

関連ノート

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