Acetyl chloride → 3-Amino-2-(Cbz-amino)-alanine Methyl Ester
反応式
[C:1](Cl)(=O)C.[NH:5]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][NH2:8]>CO>[NH2:8][CH2:7][CH:6]([NH:5][C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])[C:9]([O:11][CH3:1])=[O:10]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Acetyl chloride (0.627 ml, 8.81 mmol) was added dropwise to a suspension of commercially available Z-Dap-OH ((S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid) (1 g, 4.20 mmol) in methanol (20 ml) at 0° C. The mixture was stirred at 0° C. for 4 hours and at room temperature for 16 hours. The solvent was evaporated under vacuum to afford the title compound.
後処理
- customThe solvent was evaporated under vacuum
出典と根拠
- ORDレコード
- ord-8fb3b552e2b744769fe0693427451071
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09303035B2
反応ノート
読み込み中…