Hydrochloric Acid → 5-Fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid

HRID 624662ノート

反応式

HRID 624662 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:6]=[C:5]2[C:15]([O:17]C(C)(C)C)=[O:16].Cl>CCOC(C)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:6]=[C:5]2[C:15]([OH:17])=[O:16]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 90031845tert-Butyl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate

生成物 1

HCID 900309845-Fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of tert-butyl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate (150 mg, 0.479 mmol) and conc. HCl (0.2 ml, 2.394 mmol) in EtOAc (10 ml) was stirred at RT for 2 h. The mixture was then partially concentrated, and the resulting precipitate was collected by filtration, washed with EtOAc and dried in vacuo to afford the title compound as a white solid, which was used without further purification.

後処理

  1. concentrationThe mixture was then partially concentrated
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with EtOAc
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-0274125a8df04815ab79ff8755cea993
出典データセット
uspto-grants-2016_04
特許番号
US09303045B2

反応ノート

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