Ammonium Hydroxide → 5-Chloropyrazolo[1,5-a]pyrimidin-7-amine

HRID 624685ノート

反応式

HRID 624685 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[OH-].[NH4+:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:13])[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

生成物 1

HCID 231319095-Chloropyrazolo[1,5-a]pyrimidin-7-amine収率 88%

反応条件

温度
85 °C

実験手順

To the reaction flask, 5,7-dichloropyrazolo[1,5-a]pyrimidine (3 g, 16 mmol) was added along with ammonium hydroxide solution (48 mL). The heterogeneous reaction was refluxed at 85° C. for 12 hours. After cooling to room temperature, the mixture was filtered, washed with water, and dried under vacuum overnight. The product, 5-chloropyrazolo[1,5-a]pyrimidin-7-amine, was collected as an off-white solid in 88% yield. LCMS (M+1=169)

後処理

  1. customThe heterogeneous reaction
  2. temperatureAfter cooling to room temperature
  3. filtrationthe mixture was filtered
  4. washwashed with water
  5. customdried under vacuum overnight
  6. customThe product, 5-chloropyrazolo[1,5-a]pyrimidin-7-amine, was collected as an off-white solid in 88% yield

出典と根拠

ORDレコード
ord-da7ba9360b6e4438a5e2e7211cfe4289
出典データセット
uspto-grants-2016_04
特許番号
US09303033B2

反応ノート

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