1-(Trifluoromethyl)cyclopropanamine → HCID 71105762、化合物
反応式
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[F:21][C:22]([F:28])([F:27])[C:23]1([NH2:26])[CH2:25][CH2:24]1>>[F:21][C:22]([F:28])([F:27])[C:23]1([NH:26][C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[CH2:18][C:17]([F:20])([F:19])[CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:25][CH2:24]1参加物
3
実験手順
The title compound was synthesized in analogy to the procedure described in Example 47 b), using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) and 1-(trifluoromethyl)cyclopropanamine (CAN 112738-68-8) as starting materials. MS (EI): m/e=392.4 [M+H]+.
出典と根拠
- ORDレコード
- ord-0126a9309b5b45afb5dcbbeeb95d739f
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09303012B2