Hydrochloric Acid → 1,1-Dioxo-1,3-thiazolidine-4-carboxamide hydrochloride

HRID 624986ノート

反応式

HRID 624986 の反応式
[ClH:1].O1CCOCC1.[C:8]([CH:11]1[CH2:15][S:14](=[O:17])(=[O:16])[CH2:13][N:12]1C(OC(C)(C)C)=O)(=[O:10])[NH2:9]>ClCCl>[ClH:1].[O:16]=[S:14]1(=[O:17])[CH2:15][CH:11]([C:8]([NH2:9])=[O:10])[NH:12][CH2:13]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 90204869tert-Butyl 4-carbamoyl-1,1-dioxo-1,3-thiazolidine-3-carboxylate

生成物 1

HCID 902038431,1-Dioxo-1,3-thiazolidine-4-carboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

An ice cold 4 M solution of HCl in dioxane (4.73 mL, 18.9 mmol) was added to a solution of tert-butyl 4-carbamoyl-1,1-dioxo-1,3-thiazolidine-3-carboxylate (Example 127 c, 500 mg, 1.89 mmol) in dichloromethane (10.2 mL). The mixture was stirred for 4 d at ambient temperature. Removal of the solvent in vacuo yielded the title compound (388 mg, quant.) as white solid which was used in the next step without further purification, MS (ESI) m/e=198.99 [M−H−].

後処理

  1. customRemoval of the solvent in vacuo

出典と根拠

ORDレコード
ord-ae7109127a46434989fa047a5a919d54
出典データセット
uspto-grants-2016_04
特許番号
US09303012B2

反応ノート

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