HCID 86711148、化合物 → tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

HRID 625171ノート

反応式

HRID 625171 の反応式
[C:1]([CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH:3]1[N:8]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH2:7][CH2:6][N:5]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:4]1

参加物

4

反応物 1

HCID 86711148HCID 86711148、化合物

生成物 1

HCID 86711149tert-Butyl 3-(aminomethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl 3-cyano-4-(2-(2-hydroxyethoxy)ethyl)piperazine-1-carboxylate, prepared as described in the previous step, (9.9 g, 33.1 mmol) in methanol (20 mL) was added Raney Ni (15 g). The reaction solution was stirred at room temperature overnight under hydrogen atmosphere (50 psi). The mixture was filtered and concentrated to provide the product, which was used in the next step without additional purification.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customto provide the product, which
  4. customwas used in the next step without additional purification

出典と根拠

ORDレコード
ord-2dd9145331b94ac994de69388b47a037
出典データセット
uspto-grants-2016_04
特許番号
US09304126B2

反応ノート

読み込み中…