Diethyl Oxalate → HCID 178470312、化合物

HRID 625786

反応式

HRID 625786 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[C:12](OCC)(=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14]>CC(O)=O>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4]([OH:5])=[N:6][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:1]2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 7268Diethyl OxalateHCID 102410042-Amino-4-fluorobenzamide

生成物 1

HCID 178470312HCID 178470312、化合物収率 22%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2-amino-4-fluorobenzamide (750 mg, 4.40 mmol), diethyl oxalate (20 mL), and AcOH (8 mL) was stirred at 140° C. for 16 h. The solid was collected by filtration and dried under reduced pressure to afford ethyl 7-fluoro-4-hydroxyquinazoline-2-carboxylate as a solid (235 mg, 22%). 1H NMR (300 MHz, DMSO-d6) δ 1.36 (t, J=7.08 Hz, 2H), 4.39 (q, J=7.08 Hz, 2H), 7.52 (m, 1H), 7.67 (m, 1H), 8.25 (m, 1H), 11.97 (br s, 1H), 12.77 (br s, 1H).

後処理

  1. filtrationThe solid was collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-757e71033efc4958970f004e0b355c3d
出典データセット
uspto-grants-2016_04
特許番号
US09308207B2

関連ノート

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