化工社化工社 化学情報印刷レポート · 研究参考用
Water → Atorvastatin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Atorvastatin | HCID 60823 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Atorvastatin | HCID 60823 | — |
| 生成物 | 2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, ammonium salt | HCID 73059202 | — |
反応手順
The ammonium salt of atorvastatin was synthesized by preparing a stock solution of the free acid of atorvastatin (U.S. Pat. No. 5,273,995) in acetonitrile (ACN) (0.634 g in 25 mL of ACN). A solution was prepared by dissolving 12.04 mg of ammonium hydroxide (1.0 equivalents) in acetonitrile (0.5 mL). The stock solution of atorvastatin free acid (2.24 mL) was added to the counterion solution with stirring. If a gel formed, additional acetonitrile and water was added as necessary. After 2 days of stirring at ambient temperature, the solids were isolated by vacuum filtration using a 0.45 μm nylon 66 membrane filter. The solids were rinsed with acetonitrile and air dried at ambient conditions to afford atorvastatin ammonium.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09309195B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-9700416368944d8d9cc7726948ad6993 |
| 出典メモ | uspto-grants-2016_04 |