化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(benzyloxy)-5-bromopyridin-2(1H)-one | HCID 67406846 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one | HCID 67417860 | 87.3% |
反応手順
To a suspension of 2.51 g (8.96 mmol) 3-benzyloxy-5-bromo-1H-pyridin-2-one and 2.48 g (17.9 mmol) K2CO3 in 45 mL DMF was added 1.12 mL (17.9 mmol) iodomethane at room temperature. After stirring overnight, 150 mL water was added with vigorous stirring causing precipitation of the product which was collected by filtration and dried in vacuo affording 2.3 g (87%) 3-benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09309199B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-6dc501ab7a7043bba1f71557da576b5b |
| 出典メモ | uspto-grants-2016_04 |