関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Homovanillyl alcohol | HCID 16928 | — |
| 反応物 | 2,6-Difluoropyridine | HCID 73934 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Fluoro-6-(4-{2-[(6-fluoropyridin-2-yl)oxy]ethyl}-2-methoxyphenoxy)pyridine | HCID 24785926 | — |
反応手順
To a suspension of KOH (2 mmol; 112 mg) in anhydrous DMF (1 mL) under argon, was added 4-(2-hydroxyethyl)-2-methoxyphenol (1 mmol; 168 mg) followed by 2,6-Difluoropyridine (1 mmol; 0.1 ml). The reaction mixture was stirred at 110° C. for 20 h.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09309179B2 |
|---|
| 出典データセット | uspto-grants-2016_04 |
|---|
| ORD ID | ord-c5873df0ab9942df83120de2cb1d9f1b |
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| 出典メモ | uspto-grants-2016_04 |
|---|
