1-(3,4-Difluorophenyl)ethan-1-one → 1-{4-[2-(Benzyloxy)-4-ethylphenoxy]-3-fluorophenyl}ethanone

HRID 626059

反応式

HRID 626059 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][CH3:16])[CH:12]=[CH:11][C:10]=1[OH:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC1C([N+]([O-])=O)=NC=CC=1.[F:28][C:29]1[CH:30]=[C:31]([C:36](=[O:38])[CH3:37])[CH:32]=[CH:33][C:34]=1F>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][CH3:16])[CH:12]=[CH:11][C:10]=1[O:17][C:34]1[CH:33]=[CH:32][C:31]([C:36](=[O:38])[CH3:37])=[CH:30][C:29]=1[F:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 1230521-(3,4-Difluorophenyl)ethan-1-oneHCID 27628023-Fluoro-2-nitropyridineHCID 591912432-(Benzyloxy)-4-ethylphenol

生成物 1

HCID 591914011-{4-[2-(Benzyloxy)-4-ethylphenoxy]-3-fluorophenyl}ethanone収率 96%

実験手順

According to the procedure of example 21 (a3) except substituting 4-Ethyl-2-methoxy phenol by 2-(benzyloxy)-4-ethylphenol (1.3 g, 5.7 mmol) and 3-Fluoro-2-nitropyridine by 1-(3,4-difluorophenyl)ethanone (0.98 g, 6.27 mmol), the title compound was prepared as a clear oil in 96% yield (2 g) and used without further purification.

後処理

  1. customused without further purification

出典と根拠

ORDレコード
ord-5af2dfcfa98c421bb2f57be5933723f6
出典データセット
uspto-grants-2016_04
特許番号
US09309179B2

関連ノート

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