alpha-Methyl-4-(2-methylpropyl)benzeneacetyl chloride → 3-Acetamidobicyclo[1.1.1]pentan-1-yl 2-(4-isobutylphenyl)propanoate

HRID 62610

反応式

HRID 62610 の反応式
[OH:1][C:2]12[CH2:6][C:4]([NH:7][C:8](=[O:10])[CH3:9])([CH2:5]1)[CH2:3]2.[CH2:11]([C:15]1[CH:20]=[CH:19][C:18]([CH:21]([CH3:25])[C:22](Cl)=[O:23])=[CH:17][CH:16]=1)[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([C:15]1[CH:16]=[CH:17][C:18]([CH:21]([CH3:25])[C:22]([O:1][C:2]23[CH2:6][C:4]([NH:7][C:8](=[O:10])[CH3:9])([CH2:5]2)[CH2:3]3)=[O:23])=[CH:19][CH:20]=1)[CH:12]([CH3:14])[CH3:13]

参加物

3

反応物 2

HCID 595157alpha-Methyl-4-(2-methylpropyl)benzeneacetyl chlorideHCID 86287953N-{3-hydroxybicyclo[1.1.1]pentan-1-yl}acetamide

生成物 1

HCID 862880283-Acetamidobicyclo[1.1.1]pentan-1-yl 2-(4-isobutylphenyl)propanoate

実験手順

The general procedure of Example 1 Step 3 is repeated starting with N-(3-hydroxybicyclo[1.1.1]pentan-1-yl)acetamide (1) and using 2-(4-isobutylphenyl)propanoyl chloride in place of the acetyl chloride to produce 3-acetamidobicyclo[1.1.1]pentan-1-yl 2-(4-isobutylphenyl)propanoate (9).

出典と根拠

ORDレコード
ord-bd66d318b4f74252ae13b7b447a832ff
出典データセット
uspto-grants-2016_09
特許番号
US09447025B2

関連ノート

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