Hydrochloric Acid → (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone

HRID 626144

反応式

HRID 626144 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5](Cl)=[O:6].[Al+3].[Cl-].[Cl-].[Cl-].[Cl:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>ClCCl>[Cl:17][CH2:18][CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([C:5]([C:4]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([F:1])[CH:3]=2)=[O:6])=[CH:23][CH:22]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 12156Benzene, (2-chloroethoxy)-HCID 27792553-Fluoro-4-methoxybenzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 89656203(4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3-fluoro-4-methoxybenzoyl chloride from the last step and anhydrous AlCl3 (1.30 g, 9.76 mmol) in dry dichloromethane (18 mL) was added (2-chloroethoxy)benzene (1.53 g, 9.76 mmol) in 2 mL dichloromethane at 0° C. After stirring at rt for 25 min, the mixture was poured into 3 N HCl. The mixture was extracted with dichloromethane. The extract was washed with sat. NaHCO3 and brine, dried over Na2SO4, filtered, and concentrated to give the subtitle compound, which would be used for the next step directly.

後処理

  1. extractionThe mixture was extracted with dichloromethane
  2. washThe extract was washed with sat. NaHCO3 and brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-c756a8092d5f4cbbbcfb12df486ac58f
出典データセット
uspto-grants-2016_04
特許番号
US09309211B2

関連ノート

読み込み中…