Hydrochloric Acid → 1-(2-Chlorobenzofuran-5-yl)propan-1-one
反応式
[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]3([CH2:16][CH3:17])OCC[O:12]3)=[CH:7][C:5]=2[CH:6]=1.Cl>CO>[Cl:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11](=[O:12])[CH2:16][CH3:17])=[CH:7][C:5]=2[CH:6]=1参加物
4
実験手順
To a stirred solution of 2-chloro-5-(2-ethyl-1,3-dioxolan-2-yl)benzofuran (250 mg, 1.0 eq) in 15 mL MeOH was added 3 mL 3N HCl (aq) at rt. The reaction was stirred for 30 min at rt, quenched with sat NaHCO3 (aq), and extracted with EtOAc. The extract was washed with brine, dried, concentrated, and purified by column chromatography to give the desired product (140 mg, 68%). 1H NMR (400 MHz, CDCl3) δ 8.15 (d, J=1.6 Hz, 1H), 7.95 (dd, J=8.4 Hz, 1.6 Hz, 1H), 7.48 (d, J=8.8 Hz, 1H), 6.68 (s, 1H), 3.06 (q, J=6.8 Hz, 2H), 1.25 (t, J=6.8 Hz, 3H).
後処理
- customquenched with sat NaHCO3 (aq)
- extractionextracted with EtOAc
- washThe extract was washed with brine
- customdried
- concentrationconcentrated
- custompurified by column chromatography
出典と根拠
- ORDレコード
- ord-7e77164896204c79bb3bccb4fd870967
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309211B2
反応ノート
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