Dimethylformamide dimethyl acetal → N'-(4-cyclopropylmethoxy-2,5-dimethylphenyl)-N,N-dimethylformamidine
反応式
[CH:1]1([CH2:4][O:5][C:6]2[C:11]([CH3:12])=[CH:10][C:9]([NH2:13])=[C:8]([CH3:14])[CH:7]=2)[CH2:3][CH2:2]1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH:1]1([CH2:4][O:5][C:6]2[C:11]([CH3:12])=[CH:10][C:9]([N:13]=[CH:17][N:18]([CH3:20])[CH3:19])=[C:8]([CH3:14])[CH:7]=2)[CH2:2][CH2:3]1参加物
3
実験手順
A mixture of 0.23 g of 4-cyclopropylmethoxy-2,5-dimethylphenylamine and 10 mL of N,N-dimethylformamide dimethylacetal was stirred under heating and refluxing for 10 hours. The cooled reaction mixture was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 0.18 g of N′-(4-cyclopropylmethoxy-2,5-dimethylphenyl)-N,N-dimethylformamidine (Compound of Present Invention (1-17)).
後処理
- temperatureunder heating
- temperaturerefluxing for 10 hours
- customThe cooled reaction mixture
- concentrationwas concentrated under reduced pressure