Triethylamine → 1H-Indole-2-carboxamide
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([OH:12])=O.C[N:14](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(CC)CC>CN(C=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH2:14])=[O:12]参加物
5
実験手順
To indole-2-carboxylic acid (1e) (500 μL, 0.2 M in anhydrous DMF) was added HATU (250 μL, 0.4 M in anhydrous DMF) and Et3N (50 μL, 2.0 M in anhydrous DMF) and stirred for 5 minutes at room temperature. The desired amine (R6—NH2) was dissolved in 520 μL anhydrous DMF and added to the reaction mixture. The reaction mixture was stirred for two hours at 45° C. and the solvent was evaporated in vacuo and the residue was purified via preparative HPLC to obtain the desired product indole-2-carboxamide (I).
後処理
- additionadded to the reaction mixture
- stirringThe reaction mixture was stirred for two hours at 45° C.
- customthe solvent was evaporated in vacuo
- customthe residue was purified via preparative HPLC
出典と根拠
- ORDレコード
- ord-e66f91d3cee4486fb48425e2aee0cf67
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447039B2
反応ノート
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