2-Methylcyclohexanone → HCID 178424364、化合物

HRID 62658

反応式

HRID 62658 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[C:9]1([C@H:15]([NH2:17])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4]/[C:3]/1=[N:17]\[C@@H:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:16]

参加物

4

反応物 2

HCID 114192-MethylcyclohexanoneHCID 6431891-Phenethylamine, (+)-

生成物 1

HCID 178424364HCID 178424364、化合物収率 84%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A stirred solution of 2-methylcyclohexanone (5 g, 44.64 mmol) and (R)-1-phenylethanamine (5.4 g, 44.64 mmol) in toluene (50 mL) was maintained at 140-145° C. for 24 h. The solvent was removed under reduced pressure to afford 8 g (84%) of a diastereomeric mixture of (1R,E)-N-(2-methylcyclohexylidene)-1-phenylethanamine (I-8a) as a pale yellow oil.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a6494b17610041718444964d445c6e04
出典データセット
uspto-grants-2016_09
特許番号
US09447039B2

関連ノート

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